The carbapenems are β-lactam antimicrobial agents with an exceptionally broad spectrum
of activity. Older carbapenems, such as imipenem, were often susceptible to degradation by …

The new fluoroquinolones (clinafloxacin, gatifloxacin, gemifloxacin, grepafloxacin, levofloxacin,
moxifloxacin, sitafloxacin, sparfloxacin and trovafloxacin) offer excellent activity against …

Vancomycin utilisation has increased dramatically in the last 10 years due to the increasing
clinical significance of infections with methicillin-resistant staphylococci. Recent studies have …

Avibactam (formerly NXL104, AVE1330A) is a synthetic non-β-lactam, β-lactamase inhibitor
that inhibits the activities of Ambler class A and C β-lactamases and some Ambler class D …

With the expanded use of fluoroquinolones for the treatment of community-acquired respiratory
infections and reports of tendon injury linked to the use of these agents, we reviewed the …

The tetracycline class of antimicrobials exhibit a broad-spectrum of activity against numerous
pathogens, including Gram-positive and Gram-negative bacteria, as well as atypical …

The first macrolide, erythromycin A, demonstrated broad-spectrum antimicrobial activity and
was used primarily for respiratory and skin and soft tissue infections. Newer 14-, 15- and 16-…

Relebactam (formerly known as MK-7655) is a non-β-lactam, bicyclic diazabicyclooctane, β-lactamase
inhibitor that is structurally related to avibactam, differing by the addition of a …

Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are important
causes of morbidity and mortality, with mortality rates approaching 62%. HAP and VAP …

Background Asymptomatic bacteriuria is common among women with diabetes, and the
treatment of such infections has been recommended to prevent complications related to …