An easy and safe dose‐response histamine‐inhalation test is described, to measure the
level of non‐specific bronchial reactivity. The test was performed in 307 subjects. Non‐specific …

BACKGROUND: Airway inflammation is considered to be important in asthma but is relatively
inaccessible to study. Less invasive methods of obtaining sputum from patients unable to …

Background Eosinophilic inflammation, which may be a consequence of interleukin-5 action,
is a characteristic feature of some forms of asthma. However, in three previous clinical trials …

Methods to examine sputum for indices of airway inflammation are evolving. We have
examined the repeatability and the validity of an improved method to measure sputum cells and …

Abbreviations: ACE angiotensin-converting enzyme; ACP American College of Physicians;
A/D antihistamine/decongestant; ATS American Thoracic Society; BPC bronchoprovocation …

Non‐allergic bronchial hyper‐reactivity is a feature of most patients with asthma. We have
measured non‐allergic bronchial reactivity to inhaled histamine and methacholine in thirteen …

Clinicians have been interested in the macroscopic and protocol (fig 1), based on that
described by Pin et al7 using a relatively low output ultrasonic nebuliser (output 0.9 ml/…

One important goal of asthma treatment is to reduce exacerbations. The current authors
investigated if the use of sputum cell counts to guide treatment would achieve this goal. A total of …

Sputum cell-counts were studied in 7 non-smokers with corticosteroid-responsive chronic
cough productive of sputum and 8 smokers with a clinical diagnosis of chronic bronchitis, all of …

Several short-term studies have shown that inhaled steroids can reduce airway
hyperresponsiveness in asthma. To evaluate whether prolonged treatment can bring about full …