Background Major depressive disorder is one of the most common, burdensome, and costly
psychiatric disorders worldwide in adults. Pharmacological and non-pharmacological …

Background Evidence-based medicine is valuable to the extent that the evidence base is
complete and unbiased. Selective publication of clinical trials — and the outcomes within those …

Background In animals, the circadian pacemaker regulates seasonal changes in behavior
by transmitting a signal of day length to other sites in the organism. The signal is expressed …

This paper reviews the preclinical and clinical evidence regarding the use of the dietary
supplement 5-hydroxytryptophan (5-HTP) for the treatment of depression. In the absence of …

Johnson is a consultant for the American College of Sports Medicine. Scott Patten is a consultant
for Cipher Pharmaceuticals and Servier Canada; he has provided expert testimony for …

Background The efficacy of antidepressant medication has been shown empirically to be
overestimated due to publication bias, but this has only been inferred statistically with regard to …

Background: The modern practice of using artificial light to extend waking activities into the
nighttime hours might be expected to precipitate or exacerbate bipolar illness, because it has …

Background Randomized trials can show whether a treatment effect is statistically significant
and can describe the size of the effect. There are, however, no validated methods available …

Background A large proportion of mindfulness-based therapy trials report statistically
significant results, even in the context of very low statistical power. The objective of the present …

Objective To assess the performance of novel contour enhanced funnel plots and a regression
based adjustment method to detect and adjust for publication biases. Design Secondary …