… By the time of the survey of McGeer et al., salicylates had been largely replaced by the
more powerful NSAIDs. Breitner et al. [12] did an orthogonal comparison of the effect of aspirin …

Cultured brain cells are capable of generating many molecules associated with inflammatory
and immune functions. They constitute the endogenous immune response system of brain. …

… The epidemiological evidence of microglial attack is more robust than in PD (reviewed by
McGeer and McGeer17) but, except for promising results in pilot studies of indomethacin and …

We detected large numbers of HLA-DR-positive reactive microglia (macrophages), along with
Lewy bodies and free melanin, in the substantia nigra of all cases studied with Parkinson's …

… or a mouse monoclonal antibody indifferent to brain tissue (eg anti-leu 4, Becton Dickinson).
… 4 McGeer, PL, Itagaki, S., Mizukawa, K. and McGeer, EG, Biochemistry and pathology of the …

C-reactive protein (CRP) and complement are hypothesized to be major mediators of
inflammation in atherosclerotic plaques. We used the reverse transcriptase-polymerase chain …

SYSTEMIC administration of large doses of L-glutamate to immature animals causes
degeneration of neurones in the retina and the arcuate nucleus. Olney et al. reported that …

It has been hypothesized that idiopathic parkinsonism might be due to age‐related attrition
of dopamine neurons occurring long after an initial acute episode. We present evidence …

… and McGeer, PL 119901 Brain microglia constitutively express [32 integrins. J . … PI., Tt,agaki,
S.: and McGeer, EG 11988) Expression of the histocompatibility glycoprotein HIADR in …

Chronic inflammation is associated with a broad spectrum of neurodegenerative diseases
of aging. Included are such disorders as Alzheimer's disease (AD), Parkinson's disease (PD), …