Background Patients with elevated triglyceride levels are at increased risk for ischemic
events. Icosapent ethyl, a highly purified eicosapentaenoic acid ethyl ester, lowers triglyceride …

Background Prior unblinded studies have suggested that catheter-based renal-artery denervation
reduces blood pressure in patients with resistant hypertension. Methods We designed …

Background The cardiovascular safety profile of dapagliflozin, a selective inhibitor of sodium–glucose
cotransporter 2 that promotes glucosuria in patients with type 2 diabetes, is …

Aim This clinical practice guideline for the evaluation and diagnosis of chest pain provides
recommendations and algorithms for clinicians to assess and diagnose chest pain in adult …

Purpose— Our goal is to provide an overview of the current evidence about components of
the evaluation and treatment of adults with acute ischemic stroke. The intended audience is …

Background The cardiovascular safety and efficacy of many current antihyperglycemic agents,
including saxagliptin, a dipeptidyl peptidase 4 (DPP-4) inhibitor, are unclear. Methods We …

Background Dual antiplatelet therapy with clopidogrel plus low-dose aspirin has not been
studied in a broad population of patients at high risk for atherothrombotic events. Methods We …

Background Increases in lipid levels and cancers with tofacitinib prompted a trial of major
adverse cardiovascular events (MACE) and cancers in patients with rheumatoid arthritis …

Advances in antithrombotic therapy, along with an early invasive strategy, have reduced the
incidence of recurrent ischemic events and death in patients with acute coronary syndromes …

comprehensive review of the published evidence for management of a given condition
according to ESC Committee for Practice Guidelines (CPG) policy. A critical evaluation of …