OBJECTIVE—Metformin is considered contraindicated in patients with heart failure because
of concerns over lactic acidosis, despite increasing evidence of potential benefit. The aim of …

Objective To identify the most commonly presenting conditions in primary care globally, and
to compare common reasons for visits (RFVs) as reported by clinicians and patients, as well …

Methods The overarching goals and methodologic principles for the Diabetes Canada CPG
are unchanged from 2018 (2, 3). Leveraging the search methods and PICO questions used …

Background Esophageal adenocarcinoma (EAC) often presents at a late, incurable stage,
and mortality has increased substantially, due to an increase in incidence of EAC arising out …

Objective To evaluate progressive cerebral degeneration in amyotrophic lateral sclerosis (ALS)
by assessing alterations in N-acetylaspartate (NAA) ratios in the motor and prefrontal …

Objective To evaluate the relation between adherence to drug therapy, including placebo,
and mortality. Design Meta-analysis of observational studies. Data sources Electronic …

Objective To review the literature on the association between antidiabetic agents and morbidity
and mortality in people with heart failure and diabetes. Design Systematic review and …

Background— There is an ongoing controversy regarding the safety and effectiveness of
metformin in the setting of heart failure (HF). Therefore, we undertook a systematic review of the …

Objectives To determine whether statins reduce mortality or need for admission to intensive
care in patients admitted to hospital with community acquired pneumonia; and to assess …

Background: Over the past 30 years, the relation between use of sulfonylureas to treat type
2 diabetes and the risk of cardiovascular events has been vigorously debated. The purpose …