Background: Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active
metabolite. The clinical significance of this drug interaction is unknown. Methods: We …

Importance Opioid prescribing and overdose are leading public health problems in North
America, yet the precise public health burden has not been quantified. Objective To examine …

The Stanford–Lancet Commission on the North American Opioid Crisis was formed in response
to soaring opioid-related morbidity and mortality in the USA and Canada over the past …

Objective To characterise whether some selective serotonin reuptake inhibitor (SSRI)
antidepressants reduce tamoxifen’s effectiveness by inhibiting its bioactivation by cytochrome …

Introduction. Colchicine is used mainly for the treatment and prevention of gout and for familial
Mediterranean fever (FMF). It has a narrow therapeutic index, with no clear-cut distinction …

Context Osteoporosis is associated with significant morbidity and mortality. Oral bisphosphonates
have become a mainstay of treatment, but concerns have emerged that long-term use …

Background Non-selective, non-steroidal anti-inflammatory drugs (NSAIDs) are associated
with an increased risk of congestive heart failure, but little is known about the cardiovascular …

Both chloroquine and hydroxychloroquine interfere with ventricular repolarization, leading
to prolongation of the QTc interval and an increased risk of torsades de pointes (TdP). This …

Background The Randomized Aldactone Evaluation Study (RALES) demonstrated that
spironolactone significantly improves outcomes in patients with severe heart failure. Use of …

Background Prior studies suggest that unintended medication discrepancies that represent
errors are common at the time of hospital admission. These errors are particularly worthy of …