User profiles for David E.C. Cole
David EC ColeProfessor of Laboratory Medicine and Pathobiology, University of Toronto Verified email at utoronto.ca Cited by 28006 |
[HTML][HTML] Vitamin D in adult health and disease: a review and guideline statement from Osteoporosis Canada
Methods We systematically searched the MEDLINE database, for the period 1996 to June
30, 2008, and the Cochrane Library using the terms “vitamin D,”“vitamin D deficiency,”“25-…
30, 2008, and the Cochrane Library using the terms “vitamin D,”“vitamin D deficiency,”“25-…
Magnesium transport in the renal distal convoluted tubule
…, D Kerstan, HS Kang, DEC Cole… - Physiological …, 2001 - journals.physiology.org
The distal tubule reabsorbs ∼10% of the filtered Mg 2+ , but this is 70–80% of that delivered
from the loop of Henle. Because there is little Mg 2+ reabsorption beyond the distal tubule, …
from the loop of Henle. Because there is little Mg 2+ reabsorption beyond the distal tubule, …
Mutations of the calcium‐sensing receptor (CASR) in familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant …
…, L D'Souza‐Li, B Yang, L Canaff, DEC Cole - Human …, 2000 - Wiley Online Library
The calcium‐sensing receptor (CASR) is a plasma membrane G protein coupled receptor
that is expressed in the parathyroid hormone (PTH) producing chief cells of the parathyroid …
that is expressed in the parathyroid hormone (PTH) producing chief cells of the parathyroid …
Ancient human genomes suggest three ancestral populations for present-day Europeans
We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old
hunter-gatherers from Luxembourg and Sweden. We analysed these and other …
hunter-gatherers from Luxembourg and Sweden. We analysed these and other …
[PDF][PDF] Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer
A population-based series of 649 unselected incident cases of ovarian cancer diagnosed in
Ontario, Canada, during 1995–96 was screened for germline mutations in BRCA1 and …
Ontario, Canada, during 1995–96 was screened for germline mutations in BRCA1 and …
Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2
HM Trang, DEC Cole, LA Rubin, P Andreas… - The American journal of …, 1998 - Elsevier
In all species tested, except humans, biological differences between vitamins D 2 and D 3
are accepted as fact. To test the presumption of equivalence in humans, we compared the …
are accepted as fact. To test the presumption of equivalence in humans, we compared the …
Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin–cohort study in Ontario, Canada
Background: BRCA1 and BRCA2 mutations in general populations and in various types of
cancers have not been well characterized. We investigated the presence of these mutations …
cancers have not been well characterized. We investigated the presence of these mutations …
Association of neural tube defects and folic acid food fortification in Canada
Many women do not receive folic acid supplements before conception. In response, most of
Canada's cereal grain products were being fortified with folic acid by January, 1998, thereby …
Canada's cereal grain products were being fortified with folic acid by January, 1998, thereby …
Occult carcinoma in prophylactic oophorectomy specimens: prevalence and association with BRCA germline mutation status
Prophylactic oophorectomy (PO) is an option for women at increased risk for ovarian
carcinoma. In this study the value of intensive pathologic examination of PO specimens and …
carcinoma. In this study the value of intensive pathologic examination of PO specimens and …
Type 2 diabetes mellitus and inflammation: Prospects for biomarkers of risk and nutritional intervention
Obesity is a major risk factor for type 2 diabetes mellitus (T2DM), which is a significant health
problem worldwide. Active disease is associated with low-grade chronic inflammation …
problem worldwide. Active disease is associated with low-grade chronic inflammation …