Background Nerinetide, an eicosapeptide that interferes with post-synaptic density protein
95, is a neuroprotectant that is effective in preclinical stroke models of ischaemia-reperfusion. …

Background Unruptured intracranial aneurysms (UIAs) are increasingly diagnosed and are
commonly treated using endovascular treatment or microsurgical clipping. The safety and …

Hyperinsulinemic hypoglycemia (HI) and congenital polycystic kidney disease (PKD) are rare,
genetically heterogeneous disorders. The co-occurrence of these disorders (HIPKD) in 17 …

Background Primary distal renal tubular acidosis (dRTA) is a rare disorder, and we aimed to
gather data on treatment and long-term outcome. Methods We contacted paediatric and …

The clinical diagnosis of inherited renal tubulopathies can be challenging as they are rare
and characterized by significant phenotypic variability. Advances in sequencing technologies …

OBJECTIVE The Flow Diversion in the Treatment of Intracranial Aneurysm Trial (FIAT) was
designed to guide the clinical use of flow diversion, an innovative method to treat intracranial …

Background Bartter and Gitelman syndromes are autosomal recessive disorders of renal
tubular salt handling. Due to their rarity, limited long-term data are available to inform prognosis …

Objective. This study was undertaken to characterize the phenotype and response to treatment
in patients with autosomal dominant FMF caused by MEFV p.M694del mutation and to …

Background For many patients with kidney failure, the cause and underlying defect remain
unknown. Here, we describe a novel mechanism of a genetic order characterized by renal …

The paper work presents the STL file format, which is now used for transferring information
from CAD software to a 3D printer, for obtaining the solid model in Rapid prototyping and …