User profiles for D. Sussman

Daniel Lewis Sussman

- Verified email at bu.edu - Cited by 3017

Daniel M. Sussman

- Verified email at emory.edu - Cited by 2307

Statistical inference on random dot product graphs: a survey

…, K Levin, V Lyzinski, Y Qin, DL Sussman - Journal of Machine …, 2018 - jmlr.org
… For random dot product graphs more generally, we show in Sussman et al. (2014) that the
latent … If XX is, in fact, a rank d matrix, we say A is the adjacency matrix of a rank d random dot …

Systematic review with network meta‐analysis: the efficacy of anti‐TNF agents for the treatment of Crohn's disease

…, AR Deshpande, DA Sussman… - Alimentary …, 2014 - Wiley Online Library
… Development Awards (Waljee, Saini), American Cancer Society, Bankhead-Coley Team
Science Program, Sylvester Comprehensive Cancer Center, Olympus America (Sussman). The …

Challenges and possible solutions to colorectal cancer screening for the underserved

S Gupta, DA Sussman, CA Doubeni… - Journal of the …, 2014 - academic.oup.com
Colorectal cancer (CRC) is a leading cause of cancer mortality worldwide. CRC incidence
and mortality can be reduced through screening. However, in the United States, screening …

[PDF][PDF] Saturated reconstruction of a volume of neocortex

…, WG Roncal, JT Vogelstein, R Burns, DL Sussman… - Cell, 2015 - cell.com
We describe automated technologies to probe the structure of neural tissue at nanometer
resolution and use them to generate a saturated reconstruction of a sub-volume of mouse …

Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development

SB Rosso, D Sussman, A Wynshaw-Boris… - Nature …, 2005 - nature.com
Dendritic arborization is required for proper neuronal connectivity. Rho GTPases have been
implicated in the regulation of dendrite development. However, the signaling pathways that …

[HTML][HTML] Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1

…, KE Stevens, G Maccaferri, CJ McBain, DJ Sussman… - Cell, 1997 - cell.com
Mice completely deficient for Dvl1, one of three mouse homologs of the Drosophila segment
polarity gene Dishevelled, were created by gene targeting. Dvl1- deficient mice are viable, …

SGN-CD33A: a novel CD33-targeting antibody–drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML

…, I Stone, MC Ryan, D Sussman… - Blood, The Journal …, 2013 - ashpublications.org
Outcomes in acute myeloid leukemia (AML) remain unsatisfactory, and novel treatments are
urgently needed. One strategy explores antibodies and their drug conjugates, particularly …

[HTML][HTML] Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1

…, DJ Sussman, J Jonkers, D Kimelman, D Wu - The EMBO …, 1999 - embopress.org
Wnt proteins transduce their signals through dishevelled (Dvl) proteins to inhibit glycogen
synthase kinase 3β (GSK), leading to the accumulation of cytosolic β-catenin and activation of …

Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure

…, J Wang, Y Yang, Z Luo, L Mei, KR Chien, DJ Sussman… - 2002 - journals.biologists.com
The murine dishevelled 2 (Dvl2) gene is an ortholog of theDrosophila segment polarity
gene Dishevelled, a member of the highly conserved Wingless/Wnt developmental pathway.Dvl2-…

Computational redesign of endonuclease DNA binding and cleavage specificity

…, D Sussman, RJ Monnat Jr, BL Stoddard, D Baker - Nature, 2006 - nature.com
The reprogramming of DNA-binding specificity is an important challenge for computational
protein design that tests current understanding of protein–DNA recognition, and has …