Lipoprotein lipase (LPL) has its physiological site of action at the luminal surface of capillary
endothelial cells where the enzyme hydrolyses the triacylglycerol component of circulating …

The metabolic phenotype of hearts has been investigated using rodent models of type 2
diabetes which exhibit obesity and insulin resistance: db/db and ob/ob mice, and Zucker fatty …

Agonist-stimulated phospholipid turnover can generate diacylglycerol (DAG), an intracellular
second messenger that activates protein kinase C (PKC). DAG can be produced from the …

… DD and Severson, DL, unpublished observations). The absence of significant contractile
dysfunction in hearts from Zucker rats (33) suggests that insulin resistance without overt signs of …

Glucose and palmitate metabolism and contractile function were measured with ex vivo
perfused working hearts from control (db/+) and diabetic (db/db) female mice at 6, 10–12, and 16…

… Address for reprint requests and other correspondence: DL Severson, Dept. of Pharmacology
and Therapeutics, Faculty of Medicine, 3330 Hospital Drive NW, Calgary, Alberta, Canada …

Altered cardiac metabolism and function (diabetic cardiomyopathy) has been observed in
diabetes. We hypothesize that cardiac efficiency, the ratio of cardiac work (pressure-volume …

In mammalian tissues, two types of regulation of the pyruvate dehydrogenase complex have
been described: end product inhibition by acetyl CoA and NADH; and the interconversion of …

Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor transcription
factor that has an important role in controlling cardiac metabolic gene expression. We …

Hearts from diabeticdb/db mice, a model of Type 2 diabetes, exhibit left ventricular failure and
altered metabolism of exogenous substrates. Peroxisome proliferator-activated receptor-α (…