Objective To compare the effects of treatments for coronavirus disease 2019 (covid-19).
Design Living systematic review and network meta-analysis. Data sources WHO covid-19 …

Context Theory and simulation suggest that randomized controlled trials (RCTs) stopped early
for benefit (truncated RCTs) systematically overestimate treatment effects for the outcome …

… of primacy, (b) the composite end point used to calculate the sample size, (c) authors'
attribution of importance to the composite end point in their description of the results, and (d) the …

… Author Contributions: Dr Devereaux and Ms Heels-Ansdell had full access to all of the data
in the study and take responsibility for the integrity of the data and the accuracy of the data …

… Diane Heels-Ansdell provided statistical expertise, analysis and interpretation of data and
critical revision of the manuscript. All authors gave approval of the final version to be published…

Background: Fluid resuscitation is the cornerstone of sepsis treatment. However, whether
balanced or unbalanced crystalloids or natural or synthetic colloids confer a survival …

Objective To investigate the credibility of authors’ claims of subgroup effects using a representative
sample of recently published randomised controlled trials. Design Systematic review. …

Methods: We searched several electronic databases up to July 2011 for studies focusing on
patient-important outcomes (for example, cardiovascular disease) and secondary outcomes …

Background The effects of thromboprophylaxis with low-molecular-weight heparin, as
compared with unfractionated heparin, on venous thromboembolism, bleeding, and other …

Importance Growing interest in microbial dysbiosis during critical illness has raised
questions about the therapeutic potential of microbiome modification with probiotics. Prior …