… The thalassaemia syndromes/ DJ Weatherall and JB Clegg, … Weatherall (1964a) provided
strong evidence for allelism for … this book, published in 1965 (Weatherall 1965), it was possible …

Background Measurement of the global burden of disease with disability-adjusted life-years
(DALYs) requires disability weights that quantify health losses for all non-fatal …

Background Reliable estimates of populations affected by diseases are necessary to guide
efficient allocation of public health resources. Sickle haemoglobin (HbS) is the most common …

Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB, which
encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 and …

It is estimated that in excess of 300 000 children are born each year with a severe inherited
disorder of hemoglobin and that approximately 80% of these births occur in low- or middle-…

Background The global burden of sickle cell anaemia (SCA) is set to rise as a consequence
of improved survival in high-prevalence low- and middle-income countries and population …

Adult polycystic kidney disease (APCKD) is a common and often lethal multi-organ disease
with an autosomal dominant pattern of inheritance; approximately 1 in 1,000 people carry the …

The remarkable phenotypic diversity of the β-thalassaemias reflects the heterogeneity of
mutations at the β-globin locus, the action of many secondary and tertiary modifiers, and a wide …

This book is a completely revised new edition of the definitive reference on disorders of
hemoglobin. Authored by world-renowned experts, the book focuses on basic science aspects …

DURING THE relatively brief period in which molecular biology has been applied to human
disease, the structure, function, and synthesis of hemoglobin have been studied most …