Background: Heart failure is a leading cause of admission to hospital, but whether the incidence
of heart failure is increasing or decreasing is uncertain. We examined temporal trends in …

… Yeung MD a , Sandra Sirrs MD b , Michael YC Tsang MD a , Kenneth Gin MD a , Christina
Luong MD a , John Jue MD a , Parvathy Nair MD a , Pui K. Lee MD a , Teresa SM Tsang MD a …

Fabry disease (FD) is an X-linked lysosomal storage disorder caused by mutations in the
galactosidase A (GLA) gene that result in deficient galactosidase A enzyme and subsequent …

The coiled-coil domain of the tripartite motif (TRIM) family protein TRIM5α is required for
trimerization and function as an antiretroviral restriction factor. Unlike the coiled-coil regions of …

Background Patients with heart failure with preserved ejection fraction (HFpEF) may have
elevated left ventricular filling pressure with exercise (LVFP-ex), despite normal LVFP at rest. …

Many tripartite motif (TRIM) proteins self-associate, forming dimers and higher order complexes.
For example, dimers of TRIM5α, a host factor that restricts retrovirus infection, assemble …

Background Unlike left ventricular (LV) ejection fraction, which provides a precise, reliable,
and prognostically valuable measure of systolic function, there is no single analogous …

Objective To keep health care providers, in response to the ongoing coronavirus disease
2019 (COVID-19) pandemic, informed about the medications that have been proposed to treat …

In owl monkeys, the typical retroviral restriction factor of primates, TRIM5α, is replaced by
TRIMCyp. TRIMCyp consists of the TRIM5 RING, B-box 2 and coiled-coil domains, as well as …

We sought to determine the cardiac ultrasound view of greatest quality using a machine
learning (ML) approach on a cohort of transthoracic echocardiograms (TTE) with abnormal left …