… Adapted with permission from Holgate and Davies (Hogrefe & Huber Publishers, Seattle, …
Reproduced with permission from Holgate and Davies (Hogrefe & Huber Publishers, Seattle, …

During lung development, repair, and inflammation, local production of cytokines (eg,
transforming growth factor-β) and growth factors (eg, epidermal growth factor) by epithelial and …

Asthma is increasing in prevalence in the developing world, affecting ∼10% of the world’s
population. It is characterised by chronic lung inflammation and airway remodelling …

… Davies; Asthmatic bronchial epithelial cells have a deficient innate immune response to
infection with rhinovirus . J Exp Med 21 March 2005; 201 (6): 937–947. doi: https://doi.org/…

Rhinoviruses are the major cause of asthma exacerbations, and asthmatics have increased
susceptibility to rhinovirus and risk of invasive bacterial infections. Here we show deficient …

Asthma exacerbations are among the most frequent causes of hospitalization during
childhood, but the underlying mechanisms are poorly understood. We performed a genome-wide …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection carries
a substantial risk of severe and prolonged illness; treatment options are currently limited. …

… Puddicombe, SM, Polosa, R., Richter, A., Krishna, MT, Howarth, PH, Holgate, ST, Davies,
DE Involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J. …

Background Asthma is characterized pathologically by structural changes in the airway,
termed airway remodeling. These changes are associated with worse long-term clinical …

BACKGROUND: Asthma is a complex disease involving gene and environment interactions.
Although atopy is a strong predisposing risk factor for asthma, local tissue susceptibilities …