Background Despite ongoing efforts aimed to improve treatment engagement for people with
substance-related disorders, evidence shows modest rates of utilization as well as client-…

Background Whether used for pain management or recreation, opioids have a number of
adverse effects including hormonal imbalances. These imbalances have been reported to …

Opioid agonist therapy was introduced in Canada in 1959 with the use of methadone for the
treatment of opioid dependence. The regulation of methadone was the responsibility of …

Background Studies in Europe have suggested that injectable diacetylmorphine, the active
ingredient in heroin, can be an effective adjunctive treatment for chronic, relapsing opioid …

… Oliver KJ, Friedman SR, Maynard H, Magnuson L, Des Jarlais DC. Impact of a needle
exchange program on potentially infectious syringes in public places. J Acquir Immune Defic …

Importance Diacetylmorphine hydrochloride (the active ingredient in heroin), delivered under
supervision, is effective for the treatment of severe opioid use disorder. However, owing to …

Objective Opioid use disorder has been declared a public health crisis across North America
and opioid agonist therapy (OAT) is the standard of care for these patients. Despite the …

Background: The Northern Ontario School of Medicine (NOSM) has a social accountability
mandate to contribute to improving the health of the people and communities of Northern …

The purposes of this study were to examine predictors of benzodiazepine use among
methadone maintenance treatment patients, to determine whether baseline benzodiazepine use …

Despite decades of experience treating heroin or prescription opioid dependence with
methadone or buprenorphine—two forms of opioid substitution therapy—gaps remain between …