Diverse functions have been reported for lipocalin 2. To investigate these functions in vivo,
we generated gene-targeted lipocalin 2-deficient mice (Lcn2 −/− mice). In vitro studies have …

The Trp53 gene family member Trp73 encodes two major groups of protein isoforms, TAp73
and ΔNp73, with opposing pro- and anti-apoptotic functions; consequently, their relative …

In thyroid, the diagnosis of papillary carcinoma (PC) is based on nuclear features; however,
identification of these features is inconsistent and controversial. Proposed markers of PC …

Papillary carcinoma (PC) represents the most common malignancy of the thyroid gland.
Therefore, the assessment of fine needle aspiration biopsies of thyroid nodules rests heavily on …

Hypophysitis can present clinically as a mass lesion of the sella turcica. Secondary hypophysitis
occurs in cases where a definite etiologic agent or process inciting the inflammatory …

Different clones, protocol conditions, instruments, and scoring/readout methods may pose
challenges in introducing different PD-L1 assays for immunotherapy. The diagnostic accuracy …

Hyalinizing trabecular tumors of the thyroid are interesting but uncommon neoplasms. They
have been classified as benign hyalinizing trabecular adenomas or malignant hyalinizing …

Based largely on studies in xenograft models, lipocalin-2 (Lcn2) has been implicated in the
progression of multiple types of human tumors, including breast cancer. Here we examine …

Among thyroid neoplasms, Hurthle cell tumors (HCTs) have traditionally been a distinct
diagnostic category. Hurthle cell adenomas are encapsulated follicular lesions with benign …

Validation of immunohistochemistry (IHC) assays is a subject that is of great importance to
clinical practice as well as basic research and clinical trials. When applied to clinical practice …