Dolutegravir–a review of the pharmacology, efficacy, and safety in the treatment of HIV

CE Kandel, SL Walmsley - Drug design, development and therapy, 2015 - Taylor & Francis
… of new antiviral agents active against hepatitis C will require pharmacokinetic studies to …
use with the direct acting agents against hepatitis C should not impact drug levels, but clinical …

[HTML][HTML] Peginterferon lambda for the treatment of outpatients with COVID-19: a phase 2, placebo-controlled randomised trial

JJ Feld, C Kandel, MJ Biondi, RA Kozak… - The Lancet …, 2021 - thelancet.com
… The interferon lambda-4 genotype, associated with response to interferon alfa and
spontaneous hepatitis C virus clearance, was assessed by sequencing rs368234815 in genomic …

[HTML][HTML] Early treatment with pegylated interferon lambda for Covid-19

…, GH Guyatt, CR Rayner, C Kandel… - … England Journal of …, 2023 - Mass Medical Soc
Background The efficacy of a single dose of pegylated interferon lambda in preventing clinical
events among outpatients with acute symptomatic coronavirus disease 2019 (Covid-19) is …

Are sink drainage systems a reservoir for hospital-acquired gammaproteobacteria colonization and infection? A systematic review

…, AJ Jamal, J Johnstone, C Kandel… - Open Forum …, 2021 - academic.oup.com
Increasing rates of antimicrobial-resistant organisms have focused attention on sink
drainage systems as reservoirs for hospital-acquired Gammaproteobacteria colonization and …

[HTML][HTML] Human sterile alpha motif domain 9, a novel gene identified as down-regulated in aggressive fibromatosis, is absent in the mouse

CF Li, JR MacDonald, RY Wei, J Ray, K Lau, C Kandel… - BMC genomics, 2007 - Springer
C. Increased expression of SAMD9 increased caspase activity in SW480 cells. D and E. …
No evidence for either gene was found in lower eukaryotes such as Drosophila, C. elegans or …

Eculizumab for treatment of rapidly progressive C3 glomerulopathy

M Le Quintrec, A Lionet, C Kandel, F Bourdon… - American Journal of …, 2015 - Elsevier
C3 glomerulopathy (C3G) is a prototypic complement-mediated kidney disease. Rapidly
progressive forms of C3G usually respond poorly to conventional treatments. We report on the …

[HTML][HTML] Detection of SARS-CoV-2 from saliva as compared to nasopharyngeal swabs in outpatients

C Kandel, J Zheng, J McCready, MA Serbanescu… - Viruses, 2020 - mdpi.com
… or QuantStudio 6); one cycle at 25 C for two minutes, one cycle at 53 C for 10 min, one cycle
at 95 C for two minutes, 40 cycles at 95 C for three seconds and 60 C for 30 s. A sample was …

Predictors of treatment failure for hip and knee prosthetic joint infections in the setting of 1-and 2-stage exchange arthroplasty: a multicenter retrospective cohort

CE Kandel, R Jenkinson, N Daneman… - Open forum …, 2019 - academic.oup.com
Background Prosthetic hip and knee joint infections (PJIs) are challenging to eradicate despite
prosthesis removal and antibiotic therapy. There is a need to understand risk factors for …

Detection of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) in outpatients: A multicenter comparison of self-collected saline gargle, oral swab, and …

CE Kandel, M Young, MA Serbanescu… - Infection Control & …, 2021 - cambridge.org
… Prior to testing, samples were inactivated by heating at 56C for 30 minutes in a dry bath filled
with thermal beads followed by a 30-second vortex. Samples were extracted by combining …

[HTML][HTML] Omicron variant neutralizing antibodies following BNT162b2 BA. 4/5 versus mRNA-1273 BA. 1 bivalent vaccination in patients with end-stage kidney disease

…, TR Tursun, Q Hu, M Dhruve, C Kandel… - Nature …, 2023 - nature.com
Neutralization of Omicron subvariants by different bivalent vaccines has not been well
evaluated. This study characterizes neutralization against Omicron subvariants in 98 individuals …