… knowledge regarding C-to-U editing consequences in the context of human disease. … bp
surrounding the target C. Two elements were described: an element 5′ to the edited C, and a 3…

… the engineering of two base editor architectures that can efficiently induce targeted C-to-G …
levels of unwanted C-to-W (W = A or T) and indel mutations. One of these C-to-G base editors (…

… Current base editors (BEs) catalyze only base transitions (C to T … C-to-A transversions in
Escherichia coli and C-to-G transversions in mammalian cells. These glycosylase base editors (…

… dual-function base editors in living cells, we constructed C→T and A→… All single-function
CBEs were only able to activate C→T … Both C→T and A→G reporter cells were activated by all …

… of adenine transversion editors has posed a particular challenge. Here we report a class of
base editors that enable efficient adenine transversion, including precise A•T-to-C•G editing. …

… Motivated by this model, we sought to develop C•G-to-G•C base editors that enhanced
uracil excision at CBE-edited nucleotides. We started with a CBE architecture lacking UGI (BE4B) …

… BE4-Gam variants offer the lowest indel frequency and highest product purity among the
base editors tested in this study. C-to-T editing efficiency/indel ratios increase as BE3 < BE3-…

… They activate both lymphocytes and macrophages from BALB/c mice and show no … /c and
CBA/J mice and ineffective in C3H/He and C57BL/6 mice [21]. When the DBA/2 and BALB/c …

… Exogenous antioxidants include the vitamins C and E and carotenoids (vitamin A precursor),
which exert their antioxidant action as free-radical scavengers. Tocopherols and flavonoids …

Chronic hepatitis C virus ( HCV ) infection leads to liver fibrosis, cirrhosis and hepatocellular
carcinoma ( HCC ). The recent Global Burden of Disease project estimated that in 2010 …