Given the number of inflammatory disorders affecting the gastrointestinal tract directly and
indirectly, coupled with the considerable overlap with functional disorders, it is evident that …

Background & Aims Most patients with Crohn’s disease (CD) eventually require an intestinal
resection. However, CD frequently recurs after resection. We performed a randomized trial …

A wealth of evidence supports the notion that curcumin, a phytochemical present in turmeric,
is a potent chemopreventive agent for colon cancer. Its mechanism of action remains …

… The prevalence of HCC is disproportionately high in areas with a high incidence of hepatitis
B virus (HBV). These areas mainly include sub-Saharan Africa and Eastern Asia[3]. It is …

It was reported previously that ceramide-1-phosphate (Cer-1-P) is mitogenic for fibroblasts (Gómez-Muñoz,
A., PA Duffy, A. Martin, L. O'Brien, HS. Byun, R. Bittman, and DN Brindley. …

Numerous therapies used for inflammatory bowel disease (IBD) target the transcription
factor NF-κB, which is involved in the production of cytokines and chemokines integral for …

Stress‐activated protein kinases (SAPKs) are activated in human inflammatory bowel disease
(IBD). Recently it has been demonstrated that p38MAPK (mitogen‐activated protein kinase…

Protein kinase CK2 has been implicated in the regulation of a wide range of proteins that
are important in cell proliferation and differentiation. Here we demonstrate that the stress …

In this report, we show for the first time that ceramide-1-phosphate (C1P) stimulates the
phosphatidylinositol 3-kinase (PI3-K)/protein kinase B (PKB) pathway, which is a major …

Background Mitogenic signaling through the principal growth factor receptor tyrosine kinase
(RTK) pathway, ie RTK--> Ras--> Raf--> Mek--> MAPK has been implicated in the …