User profiles for Arielle Elkrief
Arielle ElkriefVerified email at mail.mcgill.ca Cited by 4698 |
[HTML][HTML] Clinical impact of COVID-19 on patients with cancer treated with immune checkpoint inhibition
Background Patients with cancer who are infected with severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) are more likely to develop severe illness and die compared with …
coronavirus 2 (SARS-CoV-2) are more likely to develop severe illness and die compared with …
Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade
Abstract Treatment with combined immune checkpoint blockade (CICB) targeting CTLA-4 and
PD-1 is associated with clinical benefit across tumor types, but also a high rate of immune-…
PD-1 is associated with clinical benefit across tumor types, but also a high rate of immune-…
The role of the gut microbiome on radiation therapy efficacy and gastrointestinal complications: A systematic review
Radiation therapy (RT) is an essential component of therapy either curative or palliative
armamentarium in oncology, but its efficacy varies considerably among patients through many …
armamentarium in oncology, but its efficacy varies considerably among patients through many …
Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study
…, SA Del Prete, DB Doroshow, PC Egan, A Elkrief… - The Lancet, 2020 - thelancet.com
Background Data on patients with COVID-19 who have cancer are lacking. Here we characterise
the outcomes of a cohort of patients with cancer and COVID-19 and identify potential …
the outcomes of a cohort of patients with cancer and COVID-19 and identify potential …
Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer
…, H Pegliasco, C Richard, F Ghiringhelli, A Elkrief… - Nature medicine, 2022 - nature.com
Aside from PD-L1 expression, biomarkers of response to immune checkpoint inhibitors (ICIs)
in non-small-cell lung cancer (NSCLC) are needed. In a previous retrospective analysis, …
in non-small-cell lung cancer (NSCLC) are needed. In a previous retrospective analysis, …
Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial
Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance
to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of …
to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of …
Moving towards personalized treatments of immune-related adverse events
K Esfahani, A Elkrief, C Calabrese, R Lapointe… - Nature reviews Clinical …, 2020 - nature.com
The enhancement of immune responses upon treatment with immune checkpoint inhibitors
can have the desired outcome of reinvigorating antitumour immune surveillance, but often at …
can have the desired outcome of reinvigorating antitumour immune surveillance, but often at …
The gut microbiome associates with immune checkpoint inhibition outcomes in patients with advanced non–small cell lung cancer
T Hakozaki, C Richard, A Elkrief, Y Hosomi… - Cancer Immunology …, 2020 - AACR
The gut microbiome (GM) plays an important role in shaping systemic immune responses and
influences immune checkpoint inhibitor (ICI) efficacy. Antibiotics worsen clinical outcomes …
influences immune checkpoint inhibitor (ICI) efficacy. Antibiotics worsen clinical outcomes …
A natural polyphenol exerts antitumor activity and circumvents anti–PD-1 resistance through effects on the gut microbiota
The polyphenol castalagin isolated from a berry has an antitumor effect through direct interactions
with commensal bacteria, thus reprogramming the tumor microenvironment. In addition…
with commensal bacteria, thus reprogramming the tumor microenvironment. In addition…
Antibiotics are associated with decreased progression-free survival of advanced melanoma patients treated with immune checkpoint inhibitors
A Elkrief, L El Raichani, C Richard… - …, 2019 - Taylor & Francis
Background: The gut microbiota has been shown to be an important determinant of the efficacy
of immune checkpoint inhibitions (ICI) in cancer. Several lines of evidence suggest that …
of immune checkpoint inhibitions (ICI) in cancer. Several lines of evidence suggest that …