Importance Hypertension is the most important preventable cause of morbidity and mortality
globally, yet there are relatively few data collected using standardized methods. Objective …

Background Socioeconomic status is associated with differences in risk factors for cardiovascular
disease incidence and outcomes, including mortality. However, it is unclear whether …

Background Several studies reported a U-shaped association between urinary sodium
excretion and cardiovascular disease events and mortality. Whether these associations vary …

Chronic regional impairments of the lymphatic circulation often lead to striking architectural
abnormalities in the lymphedematous tissues. Lymphedema is a common, disabling disease …

This review presents the diagnostic features, the pathophysiology and the available therapies
for lymphedema. This disease is often able to be diagnosed by its characteristic cliniccal …

Background—Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor
of nitric oxide (NO) synthase. Because endothelial NO elaboration is impaired in …

Background The relationship between macronutrients and cardiovascular disease and
mortality is controversial. Most available data are from European and North American …

Background More than 80% of deaths from cardiovascular disease are estimated to occur in
low-income and middle-income countries, but the reasons are unknown. Methods We …

Vascular endothelial growth factor (VEGF) is known to induce the release of nitric oxide (NO)
from endothelial cells. However, the effect of NO on VEGF synthesis is not clear. …

Lymphedema—edema that results from chronic lymphatic insufficiency—is a chronic debilitating
disease that is frequently misdiagnosed, treated too late, or not treated at all. There are, …