Hereditary angioedema (HAE), a rare but life-threatening condition, manifests as acute attacks
of facial, laryngeal, genital, or peripheral swelling or abdominal pain secondary to intra-…

Hereditary Angioedema (HAE) is a rare and disabling disease for which early diagnosis and
effective therapy are critical. This revision and update of the global WAO/EAACI guideline …

Background Hereditary angioedema is characterized by recurrent attacks of angioedema of
the skin, larynx, and gastrointestinal tract. Bradykinin is the key mediator of symptoms. …

C1 inhibitor (C1-INH, also known as SERPING1) can be deficient in plasma as a result of
genetic or acquired conditions, and this causes an episodic, local increase in vascular …

Background: Angioedema without major urticarial flares (hives) is poorly understood. Its
causes are diverse, and little is known about its pathogenic mechanisms. We report on our 11 …

Importance Current treatments for long-term prophylaxis in hereditary angioedema have
limitations. Objective To assess the efficacy of lanadelumab, a fully human monoclonal antibody …

Acquired angioedema (AAE) is characterized by acquired deficiency of C1 inhibitor (C1-INH),
hyperactivation of the classical pathway of human complement and angioedema …

Background Attacks of hereditary angioedema (HAE) are unpredictable and, if affecting the
upper airway, can be lethal. Icatibant is used for physician- or patient self-administered …

Background Hereditary angioedema (HAE) is a rare, debilitating, and potentially life-threatening
disease characterized by recurrent edema attacks. Important advances in HAE …

Objective To investigate, for the first time, the frequency of recurrences of angiotensin-converting
enzyme inhibitor (ACE-I)-related angioedema after the discontinuation of ACE-I. …