The Arctic climate is changing. Permafrost is warming, hydrological processes are changing
and biological and social systems are also evolving in response to these changing …

Objective To evaluate sodium-glucose cotransporter-2 (SGLT-2) inhibitors and glucagon-like
peptide-1 (GLP-1) receptor agonists in patients with type 2 diabetes at varying …

With the centenary of the first descriptions of ‘hypersensitiveness’ following pathogenic
challenge upon us, it is appropriate to assess our current understanding of the hypersensitive …

Although highly active antiretroviral therapy (HAART) in the form of triple combinations of
drugs including protease inhibitors can reduce the plasma viral load of some HIV-1-infected …

Spanner is Google’s scalable, multiversion, globally distributed, and synchronously replicated
database. It is the first system to distribute data at global scale and support externally-…

Purpose This article introduces the new 5-level EQ-5D (EQ-5D-5L) health status measure.
Methods EQ-5D currently measures health using three levels of severity in five dimensions. A …

Background A five-level version of the EuroQol five-dimensional (EQ-5D) descriptive system
(EQ-5D-5L) has been developed, but value sets based on preferences directly elicited from …

Dengue fever is the most important mosquito-borne viral disease of humans with more than
50 million cases estimated annually in more than 100 countries 1 , 2 . Disturbingly, the …

A major challenge in predicting Earth's future climate state is to understand feedbacks that
alter greenhouse-gas forcing. Here we synthesize field data from arctic Alaska, showing that …

In all higher plants studied to date, the anthocyanin pigment pathway is regulated by a suite
of transcription factors that include Myb, bHLH and WD‐repeat proteins. However, in …