Glutamate receptors, neurotoxicity and neurodegeneration
A Lau, M Tymianski - Pflügers Archiv-European Journal of Physiology, 2010 - Springer
Glutamate excitotoxicity is a hypothesis that states excessive glutamate causes neuronal
dysfunction and degeneration. As glutamate is a major excitatory neurotransmitter in the central …
dysfunction and degeneration. As glutamate is a major excitatory neurotransmitter in the central …
Coherent detection in optical fiber systems
The drive for higher performance in optical fiber systems has renewed interest in coherent
detection. We review detection methods, including noncoherent, differentially coherent, and …
detection. We review detection methods, including noncoherent, differentially coherent, and …
Barriers to providing effective mental health services to Asian Americans
Using the research framework recommended by L. Rogler, R. Malgady, and D. Rodriguez (1989),
the current paper examines the barriers to providing effective mental health services to …
the current paper examines the barriers to providing effective mental health services to …
Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
…, SM Davidson, MR Bauer, AN Lau… - Science, 2016 - science.org
Tumor genetics guides patient selection for many new therapies, and cell culture studies
have demonstrated that specific mutations can promote metabolic phenotypes. However, …
have demonstrated that specific mutations can promote metabolic phenotypes. However, …
Tumor‐propagating cells and Y ap/T az activity contribute to lung tumor progression and metastasis
AN Lau, SJ Curtis, CM Fillmore, SP Rowbotham… - The EMBO …, 2014 - embopress.org
Metastasis is the leading cause of morbidity for lung cancer patients. Here we demonstrate
that murine tumor propagating cells ( TPC s) with the markers S ca1 and CD 24 are enriched …
that murine tumor propagating cells ( TPC s) with the markers S ca1 and CD 24 are enriched …
[HTML][HTML] Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers
…, P Mortimer, H Swaisland, A Lau… - … England Journal of …, 2009 - Mass Medical Soc
Background The inhibition of poly(adenosine diphosphate [ADP]–ribose) polymerase (PARP)
is a potential synthetic lethal therapeutic strategy for the treatment of cancers with specific …
is a potential synthetic lethal therapeutic strategy for the treatment of cancers with specific …
[HTML][HTML] Super-enhancers in the control of cell identity and disease
D Hnisz, BJ Abraham, TI Lee, A Lau, V Saint-André… - Cell, 2013 - cell.com
Super-enhancers are large clusters of transcriptional enhancers that drive expression of genes
that define cell identity. Improved understanding of the roles that super-enhancers play in …
that define cell identity. Improved understanding of the roles that super-enhancers play in …
[HTML][HTML] Selective inhibition of tumor oncogenes by disruption of super-enhancers
Chromatin regulators have become attractive targets for cancer therapy, but it is unclear
why inhibition of these ubiquitous regulators should have gene-specific effects in tumor cells. …
why inhibition of these ubiquitous regulators should have gene-specific effects in tumor cells. …
Low glycaemic diets alter lipid metabolism to influence tumour growth
Dietary interventions can change metabolite levels in the tumour microenvironment, which
might then affect cancer cell metabolism to alter tumour growth 1 , 2 , 3 , 4 – 5 . Although …
might then affect cancer cell metabolism to alter tumour growth 1 , 2 , 3 , 4 – 5 . Although …
Aspartate is an endogenous metabolic limitation for tumour growth
Defining the metabolic limitations of tumour growth will help to develop cancer therapies 1 .
Cancer cells proliferate slower in tumours than in standard culture conditions, indicating that …
Cancer cells proliferate slower in tumours than in standard culture conditions, indicating that …