Introduction Breast cancer remains a significant scientific, clinical and societal challenge.
This gap analysis has reviewed and critically assessed enduring issues and new challenges …

Tropospheric ozone plays a major role in Earth’s atmospheric chemistry processes and also
acts as an air pollutant and greenhouse gas. Due to its short lifetime, and dependence on …

Necrotizing enterocolitis (NEC) is primarily a disease process of the gastrointestinal (GI) tract
of premature neonates that results in inflammation and bacterial invasion of the bowel wall. …

We analysed whole-genome sequences of 560 breast cancers to advance understanding of
the driver mutations conferring clonal advantage and the mutational processes generating …

Background The 70-gene signature test (MammaPrint) has been shown to improve
prediction of clinical outcome in women with early-stage breast cancer. We sought to provide …

WE have hypothesized that end-to-end chromosome fusions observed in some tumours could
play a part in genetic instability associated with tumorigenesis and that fusion may result …

Approximately 1–5% of breast cancers are attributed to inherited mutations in BRCA1 or
BRCA2 and are selectively sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. In other …

The principal oxidants in the lower atmosphere are ozone (O 3 ) and two by-products of O 3
photodissociation, the hydroxyl radical (OH) and hydrogen peroxide (H 2 O 2 ). A number of …

A systematic literature review from 1966 to 2000 revealed 2,730 English‐language publications
on the role of bacteria in human primary dental caries in vivo. The most pertinent 313 …

The Georgia Tech/Goddard Global Ozone Chemistry Aerosol Radiation and Transport (GOCART)
model is used to simulate the atmospheric sulfur cycle. The model uses the …