[HTML][HTML] The organization, promoter analysis, and expression of the human PPARγ gene

…, E Raspé, K Schoonjans, AM Lefebvre… - Journal of Biological …, 1997 - ASBMB
PPARγ is a member of the PPAR subfamily of nuclear receptors. In this work, the structure of
the human PPARγ cDNA and gene was determined, and its promoters and tissue-specific …

PPARalpha and PPARgamma activators direct a distinct tissue‐specific transcriptional response via a PPRE in the lipoprotein lipase gene.

K Schoonjans, J Peinado‐Onsurbe, AM Lefebvre… - The EMBO …, 1996 - embopress.org
… :12 h day/night illumination cycle (light from 8 am to 8 pm). Rats were divided into groups of
… under ether anesthesia between 8.00 and 10.00 am Epididymal adipose tissue (in rats) and …

Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice

AM Lefebvre, I Chen, P Desreumaux, J Najib… - Nature medicine, 1998 - nature.com
The development of colorectal cancer, one of the most frequent cancers, is influenced by
prostaglandins and fatty acids 1. Decreased prostaglandin production, seen in mice with …

[HTML][HTML] Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARα and PPARγ activators

G Martin, K Schoonjans, AM Lefebvre, B Staels… - Journal of Biological …, 1997 - ASBMB
… h day:night ratio illumination cycle (light from 8 am to 8 pm). Rats were divided in groups of a
… under ether anesthesia between 8 and 10 am Epididymal adipose tissue (in rats) and liver (…

Depot-specific differences in adipose tissue gene expression in lean and obese subjects

AM Lefebvre, M Laville, N Vega, JP Riou, L Gaal… - Diabetes, 1998 - Am Diabetes Assoc
Intra-abdominal and subcutaneous adipose tissue display important metabolic differences
that underlie the association of visceral, but not subcutaneous, fat with obesity-related …

Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma.

P De Vos, AM Lefebvre, SG Miller… - The Journal of …, 1996 - Am Soc Clin Investig
The ob gene product, leptin, is a signaling factor regulating body weight and energy balance.
ob gene expression in rodents is increased in obesity and is regulated by feeding patterns …

Peroxisome proliferator-activated receptor gamma is induced during differentiation of colon epithelium cells

AM Lefebvre, B Paulweber, L Fajas… - Journal of …, 1999 - joe.bioscientifica.com
Peroxisome proliferator-activated receptor γ (PPARγ), a fatty acid-activated nuclear receptor,
is implicated in adipocyte differentiation and insulin sensitisation. In view of the association …

[HTML][HTML] Stimulation of PPARα promotes epidermal keratinocyte differentiation in vivo

LG Kömüves, K Hanley, AM Lefebvre, MQ Man… - Journal of Investigative …, 2000 - Elsevier
Our recent studies have demonstrated that PPARα activators stimulate differentiation and
inhibit proliferation in cultured human keratinocytes and accelerate epidermal development …

[HTML][HTML] Modulation of rat liver apolipoprotein gene expression and serum lipid levels by tetradecylthioacetic acid (TTA) via PPARα activation

E Raspé, L Madsen, AM Lefebvre, I Leitersdorf… - Journal of lipid …, 1999 - ASBMB
3-Thia fatty acids are modified fatty acids that promote hepatic peroxisome proliferation and
decrease serum triacylglycerol, cholesterol and free fatty acid levels in rats. In vivo …

Design of high wing loading compact electric airplane utilizing co-flow jet flow control

AM Lefebvre, GC Zha - 53rd AIAA aerospace sciences meeting, 2015 - arc.aiaa.org
This paper presents a conceptual electric airplane design utilizing Co-Flow Jet (CFJ) flow
control. The purpose is to design an aircraft with high wing loading and a compact size so that …