Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease inevitably leading
to generalized muscle weakness and premature death. Sleep disturbances are extremely …

Abstract Purpose of Review In amyotrophic lateral sclerosis (ALS), sleep disruption is
frequently present and substantially adds to disease burden. This review aims to summarize …

The exosome is a nano-sized vesicular particle commonly secreted from eukaryotic cells to
extracellular space. Exosome functions in cellular communication, nutrients or bioactive …

Quinine is a bitter tasting compound that is involved in the regulation of body weight as
demonstrated in in vivo animal models and in vitro models of the adipogenic system …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the progressive degeneration of both upper and lower motor neurons. A defining …

Sleep-related motor disorders include non-rapid-eye movement (NREM) sleep
parasomnias, rapid-eye movement (REM), sleep parasomnias including REM sleep …

OBJECTIVE There are few data available regarding the characteristics of nocturnal leg
cramps in primary care. However, this condition is particularly common among older adults …

We would like to respond to Hogan's commentary, 1 which states that quinine is not a safe
drug in the treatment of muscle cramps. Hogan points out that nonpharmacologic and other …

Sleep and Sleep Disruption in Amyotrophic Lateral Sclerosis Page 1 SLEEP (M. THORPY AND
M. BILLIARD, SECTION EDITORS) Sleep and Sleep Disruption in Amyotrophic Lateral Sclerosis …

Quinine is a bitter compound from the bark of cinchona tree commonly found in tropical
regions of the world and is a widely used antimalarial drug with neuromodulatory effect that …