Pleiotropic effects of statins on the cardiovascular system
A Oesterle, U Laufs, JK Liao - Circulation research, 2017 - Am Heart Assoc
The statins have been used for 30 years to prevent coronary artery disease and stroke. Their
primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic …
primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic …
COVID-19 for the cardiologist: basic virology, epidemiology, cardiac manifestations, and potential therapeutic strategies
Summary Coronavirus disease-2019 (COVID-19), a contagious disease caused by severe
acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has reached pandemic status. As …
acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has reached pandemic status. As …
[PDF][PDF] COVID-19 for the cardiologist: a current review of the virology, clinical epidemiology, cardiac and other clinical manifestations and potential therapeutic …
Summary The coronavirus disease-2019 (COVID-19), a contagious disease caused by
severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), has reached pandemic …
severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), has reached pandemic …
Statins: could an old friend help in the fight against COVID‐19?
RR Rodrigues‐Diez, A Tejera‐Muñoz… - British journal of …, 2020 - Wiley Online Library
The COVID‐19 pandemic caused by the severe acute respiratory syndrome coronavirus 2
(SARS‐CoV‐2) has overwhelmed healthcare systems requiring the rapid development of …
(SARS‐CoV‐2) has overwhelmed healthcare systems requiring the rapid development of …
PCSK9 is a critical regulator of the innate immune response and septic shock outcome
KR Walley, KR Thain, JA Russell, MP Reilly… - Science translational …, 2014 - science.org
A decrease in the activity of proprotein convertase subtilisin/kexin type 9 (PCSK9) increases
the amount of low-density lipoprotein (LDL) receptors on liver cells and, therefore, LDL …
the amount of low-density lipoprotein (LDL) receptors on liver cells and, therefore, LDL …
[HTML][HTML] Unintended effects of statins from observational studies in the general population: systematic review and meta-analysis
Background Efficacy of statins has been extensively studied, with much less information
reported on their unintended effects. Evidence from randomized controlled trials (RCTs) on …
reported on their unintended effects. Evidence from randomized controlled trials (RCTs) on …
[HTML][HTML] Statins: a viable candidate for host-directed therapy against infectious diseases
Statins were first identified over 40 years ago as lipid-lowering drugs and have been
remarkably effective in treating cardiovascular diseases. As research advanced, the …
remarkably effective in treating cardiovascular diseases. As research advanced, the …
Can LDL cholesterol be too low? Possible risks of extremely low levels
AG Olsson, B Angelin, G Assmann… - Journal of internal …, 2017 - Wiley Online Library
Following the continuous accumulation of evidence supporting the beneficial role of
reducing low‐density lipoprotein cholesterol (LDL‐C) levels in the treatment and prevention …
reducing low‐density lipoprotein cholesterol (LDL‐C) levels in the treatment and prevention …
[HTML][HTML] New possible pharmacological targets for statins and ezetimibe
M Niedzielski, M Broncel, P Gorzelak-Pabiś… - Biomedicine & …, 2020 - Elsevier
Statin therapy is the gold standard in the treatment of dyslipidemia. Understanding the
mechanisms of action of these drugs provides an opportunity to define new therapeutic …
mechanisms of action of these drugs provides an opportunity to define new therapeutic …
Population-based study of statins, angiotensin II receptor blockers, and angiotensin-converting enzyme inhibitors on pneumonia-related outcomes
EM Mortensen, B Nakashima, J Cornell… - Clinical infectious …, 2012 - academic.oup.com
Background. Studies suggest that statins and angiotensin-converting enzyme (ACE)
inhibitors might be beneficial for the treatment of infections. Our purpose was to examine the …
inhibitors might be beneficial for the treatment of infections. Our purpose was to examine the …