Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

Abstract Background Supervised injection services (SISs) have been developed to promote
safer drug injection practices, enhance health-related behaviors among people who inject …

There has been an enormous increase in interest in the use of evidence for public
policymaking, but the vast majority of work on the subject has failed to engage with the …

Canada has long contended with harms arising from injection drug use. In response to
epidemics of HIV infection and overdose in Vancouver in the mid-1990s, a range of actors …

Background Overdose from illicit drugs is a leading cause of premature mortality in North
America. Internationally, more than 65 supervised injecting facilities (SIFs), where drug …

Background Injecting drug use is a major risk factor for the acquisition and transmission of
HIV and Hepatitis C virus (HCV). Prevention of these infections among people who inject …

People who inject drugs (PWID) experience high levels of HIV/AIDS and hepatitis C (HCV)
infection that, together with injection-related complications such as non-fatal overdose and …

Abstract Background and Aims North America's overdose epidemic is increasingly driven by
fentanyl and fentanyl‐adulterated drugs. Supervised consumption sites, including low …

Aim Gambling harm is a serious public health issue affecting the health, financial security,
and social well-being of millions of people and their close relations around the world …

Background People who inject drugs (PWID) experience elevated rates of premature
mortality. Although previous studies have demonstrated the role of supervised injection …