Ascorbic acid: chemistry, biology and the treatment of cancer

J Du, JJ Cullen, GR Buettner - … et Biophysica Acta (BBA)-Reviews on …, 2012 - Elsevier
Since the discovery of vitamin C, the number of its known biological functions is continually
expanding. Both the names ascorbic acid and vitamin C reflect its antiscorbutic properties …

[HTML][HTML] High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer

F Böttger, A Vallés-Martí, L Cahn… - Journal of experimental & …, 2021 - Springer
Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer
agent when administered intravenously and in high doses (high-dose IVC). Early phase …

Vitamin C in disease prevention and cure: an overview

S Chambial, S Dwivedi, KK Shukla, PJ John… - Indian journal of clinical …, 2013 - Springer
The recognition of vitamin C is associated with a history of an unrelenting search for the
cause of the ancient haemorrhagic disease scurvy. Isolated in 1928, vitamin C is essential …

Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome

A Boretti, BK Banik - PharmaNutrition, 2020 - Elsevier
The recent outbreak of Covid19 has required urgent treatments for numerous patients. No
suitable vaccines or antivirals are available for Covid19. The efficiency against Covid19 of …

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

Q Chen, MG Espey, AY Sun, C Pooput… - Proceedings of the …, 2008 - National Acad Sciences
Ascorbic acid is an essential nutrient commonly regarded as an antioxidant. In this study, we
showed that ascorbate at pharmacologic concentrations was a prooxidant, generating …

High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy

Y Ma, J Chapman, M Levine, K Polireddy… - Science translational …, 2014 - science.org
Ascorbate (vitamin C) was an early, unorthodox therapy for cancer, with an outstanding
safety profile and anecdotal clinical benefit. Because oral ascorbate was ineffective in two …

Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo

Q Chen, MG Espey, AY Sun, JH Lee… - Proceedings of the …, 2007 - National Acad Sciences
Ascorbate (ascorbic acid, vitamin C), in pharmacologic concentrations easily achieved in
humans by iv administration, selectively kills some cancer cells but not normal cells. We …

Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy

M López-Lázaro - Cancer letters, 2007 - Elsevier
Accumulating evidence suggests that hydrogen peroxide (H2O2) plays an important role in
cancer development. Experimental data have shown that cancer cells produce high …

[BOOK][B] OZONE.

V Bocci - 2011 - Springer
Is there any reason to write a third book on the topic of oxygen-ozone therapy? The first was
written four years ago for italian physicians, who, for some time, had complained about the …

[HTML][HTML] Redox interactions of vitamin C and iron: Inhibition of the pro-oxidant activity by deferiprone

VA Timoshnikov, TV Kobzeva, NE Polyakov… - International journal of …, 2020 - mdpi.com
Ascorbic acid (AscH2) is one of the most important vitamins found in the human diet, with
many biological functions including antioxidant, chelating, and coenzyme activities. Ascorbic …