Cardiovascular diseases (CVD) are the number one cause of morbidity and death
worldwide. As estimated by the WHO, the global death rate from CVD is 31% wherein, a …

Drug reaction with eosinophilia and systemic symptoms (DReSS), also known as drug-
induced hypersensitivity syndrome (DiHS), is an uncommon severe adverse reaction to …

Investigations into the role of bioactivation in the pathogenesis of xenobiotic-induced toxicity
have been a major area of research since the link between reactive metabolites and …

Severe peripheral artery disease requires revascularization to relieve life-limiting ischemic
symptoms. Postrevascularization in-stent restenosis continues to be a problem after …

BACKGROUND: Even though clopidogrel is the most used drug for cardiovascular
prevention, resistance occurs in significant numbers. Therefore, we evaluated platelet …

Ticlopidine‐induced aplastic anemia (TIAA) is considered very uncommon. We present two
new cases, and we review 55 additional cases from the literature. The first case concerns a …

Aspirin in combination with platelet P2Y12 receptor blocker has become the mainstay
antiplatelet treatment strategy for the prevention of stent thrombosis. Ticlopidine was the first …

Background: Prevention harbors the greatest potential for reducing the societal burden from
stroke. As evidence accumulates on the multifactorial pathogenesis of vascular disease and …

Abstract Introduction According to the Italian National Report on drug use, thienopyridines
(ticlopidine, clopidogrel and prasugrel) and ticagrelor represent the most prescribed …

The development of endovascular treatment for intracranial aneurysms has established new
techniques such as balloon and stent-assistance, flow diversion and endosaccular …