Objective: To review the biochemistry and biological activities of leukotrienes, focusing on
their role in the mediation of inflammatory diseases. Data Sources: MEDLINE (1966-1994), …

The regulatory T (Treg) cells restrain immune responses through suppressor-function
elaboration that is dependent upon expression of the transcription factor Foxp3. Despite a critical …

Background: Hyperglycemia is associated with increased mortality in critically ill patients.
Randomized trials of intensive insulin therapy have reported inconsistent effects on mortality …

Idiopathic pulmonary fibrosis (IPF)/usual interstitial pneumonia is a ravaging condition of
progressive lung scarring and destruction. Anti-inflammatory therapies including corticosteroids …

This review of leukotrienes, which are lipid mediators with a broad array of clinical effects,
and leukotriene receptors considers the biochemical and physiological aspects of these …

Airway inflammation and remodeling in chronic asthma are characterized by airway
eosinophilia, hyperplasia of goblet cells and smooth muscle, and subepithelial fibrosis. We …

Inhalation of antigen in immunized mice induces an infiltration of eosinophils into the airways
and increased bronchial hyperreactivity as are observed in human asthma. We employed …

Arachidonic acid metabolites, the eicosanoids, are key mediators of allergen-induced airway
inflammation and remodeling in asthma. The availability of free arachidonate in cells for …

Acute respiratory distress syndrome is a multifactorial lung injury that continues to be associated
with high levels of morbidity and mortality. Mechanical ventilation, although lifesaving, is …

A new paradigm for asthma pathogenesis is presented in which exaggerated inflammation
and remodeling in the airways are a consequence of abnormal injury and repair responses …