Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) are
being increasingly used to model human heart diseases. hiPSC-CMs generated by earlier …

Background— Drug-induced arrhythmia is one of the most common causes of drug
development failure and withdrawal from market. This study tested whether human induced …

Background: Many patients taking statins often complain of muscle pain and weakness. The
extent to which muscle pain reflects muscle injury is unknown. Methods: We obtained …

Characterized by ventricular dilatation, systolic dysfunction, and progressive heart failure,
dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy in patients. DCM is …

Familial hypertrophic cardiomyopathy (HCM) is a prevalent hereditary cardiac disorder linked
to arrhythmia and sudden cardiac death. While the causes of HCM have been identified as …

Background— Cardiotoxicity is a leading cause for drug attrition during pharmaceutical
development and has resulted in numerous preventable patient deaths. Incidents of adverse …

Breast cancer is the most common invasive cancer in women, affecting more than 10% of
women worldwide. Microscopic analysis of a biopsy remains one of the most important …

Defects in urothelial integrity resulting in leakage and activation of underlying sensory nerves
are potential causative factors of bladder pain syndrome, a clinical syndrome of pelvic pain …

Human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs)
are promising candidate cell sources for regenerative medicine. However, despite the …

Stem-cell-based therapies hold considerable promise for regenerative medicine. However,
acute donor-cell death within several weeks after cell delivery remains a critical hurdle for …