High-throughput screening is an early critical step in drug discovery. Its aim is to screen a large
number of diverse chemical compounds to identify candidate 'hits' rapidly and accurately. …

The study of gene expression with printed arrays and prefabricated chips is evolving from a
qualitative to a quantitative science. Statistical procedures for determining quality control, …

PulseNet International is a global network dedicated to laboratory-based surveillance for
food-borne diseases. The network comprises the national and regional laboratory networks of …

Inhibition of the TOR signalling pathway by genetic or pharmacological intervention extends
lifespan in invertebrates, including yeast, nematodes and fruitflies 1 , 2 , 3 , 4 , 5 ; however, …

Glial cells produce myelin and contribute to axonal morphology in the nervous system. Two
myelin membrane proteolipids, PLP and DM20, were shown to be essential for the integrity …

Methods. Participants. Participants were referred to the study by their family physicians if they
had at least a.?-month history of symptomatic memory problems that interfered with daily …

Rapamycin was administered in food to genetically heterogeneous mice from the age of 9
months and produced significant increases in life span, including maximum life span, at each …

Rapamycin increases lifespan in mice, but whether this represents merely inhibition of lethal
neoplastic diseases, or an overall slowing in multiple aspects of aging is currently unclear. …

Rapamycin, an inhibitor of m TOR kinase, increased median lifespan of genetically heterogeneous
mice by 23% (males) to 26% (females) when tested at a dose threefold higher than …

Listeria monocytogenes (Lm) is a major human foodborne pathogen. Numerous Lm outbreaks
have been reported worldwide and associated with a high case fatality rate, reinforcing …