The hormone leptin, which is known to regulate body weight, has been shown to cause
rapid rewiring of key neurons in the arcuate nucleus (Arc) of the hypothalamus of mice …

In adult mammals, the adipocyte-derived hormone leptin acts on the brain to reduce food
intake by regulating the activity of neurons in the arcuate nucleus of the hypothalamus …

A decade ago, leptin (from the greek lepto meaning 'thin') was identified as the product of the
ob gene. 1 This adipocyte‐derived hormone was found to suppress feeding and stimulate …

The discovery of the fat hormone leptin 16 yr ago (1) heralded an explosion in obesity
research that continues to this day. The original premise that this hormone acted simply as …

Leptin affects feeding, metabolism, and neuroendocrine status. It is now clearly established
that the hypothalamus coordinates these responses, though the specific brain regions …

Studies of the fat-derived hormone leptin have provided key insights into the molecular and
neural components of feeding behavior and body weight regulation. An important challenge …

Here we summarize recent progress in the biology of leptin, concentrating on its central
nervous system (CNS) actions. The product of the ob gene, leptin is a circulating hormone …

Obesity, defined as an increase in body fat, is a growing problem in Western societies. In
Canada over 30% of the population is obese. Obesity is associated with increases in …

Obesity is a major health problem that contributes to the development of type 2 diabetes,
hypertension, dyslipidemia, and cardiovascular disease. The current pharmacological …

The increasing incidence of obesity and obesity-linked disease presents a serious global
health threat. To develop truly effective therapies to modulate food intake and promote …