Background: Severe traumatic brain injury often leads to death from withdrawal of life-sustaining
therapy, although prognosis is difficult to determine. Methods: To evaluate variation in …

The Bell Island and Wabana groups together comprise a ca. 150-m-thick succession of
interbedded clastic and chemical sedimentary rocks composed of eight distinct lithofacies that …

Few animal models exist that successfully reproduce several core associative and non-associative
behaviours relevant to post-traumatic stress disorder (PTSD), such as long-lasting …

An increasing number of preclinical investigations have suggested that the degree of expression
of the matrix metalloproteinase (MMP) family of endopeptidases may explain some of …

The evidence base for the use of medical cannabis preparations containing specific ratios of
cannabidiol (CBD) and Δ 9 -tetrahydrocannabinol (THC) is limited. While there is abundant …

Accumulating pre-clinical data suggests that matrix metalloproteinase (MMP) expression
plays a critical role in the pathophysiology of secondary brain injury. We conducted a …

Conservation translocations can restore populations and prevent extinction of threatened
species. Sourcing adequate genetic diversity is an essential consideration when planning …

Locally administered tissue plasminogen activator (TPA) accelerates clearance of
intraventricular hemorrhage (IVH), but its impact on neurologic outcomes remains unclear and …

Background The quantity of subarachnoid (SAH) and intraventricular hemorrhage (IVH)
occurring in the setting of a ruptured cerebral aneurysm is strongly associated with subsequent …

P-glycoprotein (P-gp) is an ABC transporter expressed at the blood brain barrier and
regulates the brain uptake of various xenobiotics and endogenous mediators including …