A concerted effort to tackle the global health problem posed by traumatic brain injury (TBI) is
long overdue. TBI is a public health challenge of vast, but insufficiently recognised, …

Objective: This systematic review and meta-analysis addresses the efficacy and safety of
corticosteroids in critically ill patients with sepsis. Data Sources: We updated a comprehensive …

The accuracy of the signs and tests that clinicians use to diagnose ventilator-associated
pneumonia (VAP) and initiate antibiotic treatment has not been well characterized. We sought to …

Background Vasodilatory shock that does not respond to high-dose vasopressors is associated
with high mortality. We investigated the effectiveness of angiotensin II for the treatment of …

Background: The role of remdesivir in the treatment of patients in hospital with COVID-19
remains ill defined in a global context. The World Health Organization Solidarity randomized …

Importance Growing interest in microbial dysbiosis during critical illness has raised
questions about the therapeutic potential of microbiome modification with probiotics. Prior …

Background Conflicting observational evidence exists regarding the association between
the sex of red-cell donors and mortality among transfusion recipients. Evidence to inform …

Background Characterization of the mesenchymal stromal cell (MSC) safety profile is important
as this novel therapy continues to be evaluated in clinical trials for various inflammatory …

Background: Urgent, unplanned hospital readmissions are increasingly being used to gauge
the quality of care. We reviewed urgent readmissions to determine which were potentially …

Objectives To summarise and compare the accuracy of physical examination, computed
tomography (CT), sonography of the optic nerve sheath diameter (ONSD), and transcranial …