This is a case study of a patient diagnosed with microscopic polyangiitis (MPA) and
complicated with deep vein thrombosis (DVT), who died of respiratory failure despite treatment. …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in late 2019
and 2020 is taking a severe toll on human health, and has been acknowledged as a …

Objective To study the capacity of butyrate to inhibit production of tumor necrosis factor α (TNFα)
in macrophage‐like synoviocytes (MLS) from patients with rheumatoid arthritis (RA), in …

β 2 -Glycoprotein I (β 2 -GPI) is proteolytically cleaved by plasmin in domain V (nicked β 2 -GPI),
being unable to bind to phospholipids. This cleavage may occur in vivo and elevated …

The CD95 ligand (FasL) transmembrane protein is found on activated T cells and cells
outside the immune system. A well-known turnover process of membrane FasL is mediated by …

A 74-year-old woman with recurrent fever and multiple joint pain was admitted to Hokkaido
University Hospital. Trans-esophageal echocardiogram revealed bacterial vegetation and …

BACKGROUND: Tacrolimus (TAC) was approved in Japan in 2005 for rheumatoid arthritis (RA)
patients having inadequate response to other disease-modifying anti-rheumatic drugs. …

Bioactive Fas ligand (FasL)-expressing vesicles were generated (vesicle preparation, VP)
from two cell lines overexpressing FasL. The effect of NOK-1 anti-FasL mAb (mouse IgG1) on …

Soluble CD95 (Fas) ligand (sFasL) is known to be deficient in transducing signals upon
engagement with membrane Fas. Here we report that sFasL tranduces, in synergy with non-…

The Jo2 anti-mouse CD95 monoclonal antibody induces lethality in mice characterized by
hepatocyte death and liver hemorrhage. Mice bearing a defect in Fas expression or in the Fas-…