© 2012 Canadian Medical Association or its licensors CMAJ, September 4, 2012, 184 (12)
1365 seems to be most clinically important when serum levels of alpha-1 antitrypsin are less …

Objective To review the topic of alpha-1 antitrypsin (AAT) deficiency. Method Narrative
literature review. Results Much work has been carried out on this condition with many …

Screening studies reveal a much larger number of individuals expected to have alpha-1
antitrypsin deficiency than is clinically recognized, with estimates that only about 2–10% of …

The Alpha One International Registry (AIR), a multinational research program focused on
alpha1-antitrypsin (AAT) deficiency, was formed in response to a World Health Organization …

A 60-year-old white man presents for evaluation of progressive dyspnea. He is a former
smoker with a 20-pack-year smoking history and a 10-year history of chronic obstructive …

Background Alpha-1 antitrypsin deficiency (AATD) is a rare hereditary condition that leads to
decreased circulating alpha-1 antitrypsin (AAT) levels, significantly increasing the risk of …

Alpha 1 antitrypsin deficiency is a hereditary condition characterized by low alpha 1
proteinase inhibitor (also known as alpha 1 antitrypsin [AAT]) serum levels. Reduced levels …

Objective Alpha-1-antitrypsin deficiency is a relatively prevalent, but under-diagnosed,
genetic disease. The objective of this study was to assess whether the systematic screening …

Background: The diagnosis and clinical management of adults with alpha-1 antitrypsin
deficiency (AATD) have been the subject of ongoing debate, ever since the publication of …

OBJECTIVE: alpha 1-Antitrypsin (alpha 1-AT) deficiency is a hereditary disorder
characterized by a high risk for the development of emphysema at an early age. In 1988, the …