Reason for posting: Palladone XL (hydromorphone hydrochloride) is a long-acting opioid for
chronic pain relief in patients with persistent, moderate-to-severe pain. A recent …

Background Hydromorphone, a potent analogue of morphine, has long had an important
role in pain management and is included in several international guidelines for managing …

The recent withdrawal of hydromorphone hydrochloride extended-release capsules
(Palladone; Purdue Pharma LP, Stamford, CT) from the market after pharmacokinetic data …

Objective: To review the chemistry, pharmacodynamics, pharmacokinetics, efficacy,
tolerability, dosing, and role of the Osmotic-controlled Release Oral delivery System (OROS) …

Hydrocodone is a semisynthetic opioid, which has been used for decades as a short-acting
analgesic combined with acetaminophen (or less commonly ibuprofen). Several long-acting …

Immediate release (IR) hydromorphone has experienced significant misuse and abuse. An
extended release (ER) hydromorphone formulation has been developed to provide …

Hydromorphone (HM) is a potent opioid analgesic that is commonly administered in the
emergency department (ED) and other acute care settings, such as medical surgical wards …

Background The disposition kinetics of hydromorphone generally necessitates oral
administration every 4 h of the conventional immediate-release tablet to provide sustained …

BACKGROUND:: Hydromorphone hydrochloride is a μ-opioid agonist with dose-dependent
analgesic properties. Extended-release hydromorphone hydrochloride (ER hydromorphone …

The steady-state pharmacokinetics of an extended-release formulation of hydromorphone,
OROS® hydromorphone, was investigated in a randomized, openlabel, crossover study in …