Arene oxide metabolites of aromatic anticonvulsants (phenytoin, phenobarbital, and
carbamazepine) may be involved in the pathogenesis of hypersensitivity reactions. We investigated …

Individual differences in metabolism of the sulfonamides may predispose patients to idiosyncratic
reactions. Sulfonamides are metabolized by N-acetylation (mediated by a genetically …

The use of 96-well microtiter plates and a programmable microplate reader to measure
glutathione reductase in an assay based on reduction of 5,5′-dithiobis(2-nitrobenzoic acid) by …

Traditional clinical monitoring of children with epilepsy does not appear to be sufficiently
sensitive to cognitive functioning and behavioral problems. Although subtle, these changes may …

… Rieder MJ, Shear NH, Kanee A, Tang BK, Spielberg SP. Prominence of slow acetylator
phenotype among patients with sulfonamide hypersensitivity reactions. CLIN PHARMACOL …

… Shear NH, Spielberg SP. In vitro evaluation of a toxic metabolite of sulfadiazine. Can J …
Cribb AE, Spielberg SP. An in vitro investigation of predisposition to sulfonamide idiosyncratic …

Arene oxide metabolites of phenytoin may be involved in the pathogenesis of drug-induced
hepatotoxicity. We examined individual susceptibility to toxicity from such metabolites by …

purpose: Therapy with anticonvulsants such as phenytoin, phenobarbital, and carbamazepine
can be complicated by severe hypersensitivity reactions. Previous work has suggested …

The N4-hydroxylation of sulfamethoxazole(SMX) to its hydroxy-lamine (SMX-HA) metabolite
is the first step in the formation of reactive metabolites responsible for mediating …

Study Objective: To determine whether differences in in-vitro detoxification of sulfonamide-reactive
metabolites can be detected among the lymphocytes from controls, patients with …