The transition of cells from an epithelial to a mesenchymal phenotype is a critical event during
morphogenesis in multicellular organisms and underlies the pathology of many diseases, …

Signaling pathways transmit information through protein interaction networks that are
dynamically regulated by complex extracellular cues. We developed LUMIER (for luminescence-…

Although DNA methylation is a key regulator of gene expression, the comprehensive
methylation landscape of metastatic cancer has never been defined. Through whole-genome …

Planar cell polarity (PCP) is critical for morphogenesis in metazoans. PCP in vertebrates
regulates stereocilia alignment in neurosensory cells of the cochlea and closure of the neural …

Mutations in the transcription factor FOXA1 define a unique subset of prostate cancers but
the functional consequences of these mutations and whether they confer gain or loss of …

Half of all prostate cancers are caused by the TMPRSS2–ERG gene-fusion, which enables
androgens to drive expression of the normally silent E26 transformation-specific (ETS) …

Mental fatigue in drivers is one of the leading causes that give rise to traffic accidents.
Electroencephalography (EEG)-based driving fatigue studies showed promising performance in …

The role of polarity signaling in cancer metastasis is ill defined. Using two three-dimensional
culture models of mammary epithelial cells and an orthotopic mouse model of breast cancer…

Here, a technique for automated detection of epilepsy is proposed, based on a novel set of
features derived from the multifractal spectrum of electroencephalogram (EEG) signals. In …

In prostate cancer, 5-hydroxymethylcytosine delineates oncogene activation and stage-specific
cell states and can be analyzed in liquid biopsies to detect cancer phenotypes. See …