Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means
RA Kroll, EA Neuwelt - Neurosurgery, 1998 - journals.lww.com
OBJECTIVE: This article reviews historical aspects of the blood-brain barrier (BBB) and recent
advances in mechanisms to deliver therapeutic agents across the BBB for the treatment of …
advances in mechanisms to deliver therapeutic agents across the BBB for the treatment of …
A positron emission tomography study of silent and oral single word reading in stuttering and nonstuttering adults
LFD Nil, RM Kroll, S Kapur, S Houle - Journal of Speech, Language, and …, 2000 - ASHA
Over the last decade positron emission tomography (PET) has been used extensively for the
study of language and other cognitive and sensorimotor processes in healthy and diseased …
study of language and other cognitive and sensorimotor processes in healthy and diseased …
Increasing volume of distribution to the brain with interstitial infusion: dose, rather than convection, might be the most important factor
RA Kroll, MA Pagel, LL Muldoon… - …, 1996 - journals.lww.com
THE VOLUME OF distribution in tissue (V t) that can be achieved by direct interstitial infusion
of therapeutic agents into brain is limited. The maintenance of a pressure gradient during …
of therapeutic agents into brain is limited. The maintenance of a pressure gradient during …
A positron emission tomography study of short-and long-term treatment effects on functional brain activation in adults who stutter
LF De Nil, RM Kroll, SJ Lafaille, S Houle - Journal of fluency disorders, 2003 - Elsevier
Previous studies have shown that fluency-inducing techniques, such as choral speech, result
in changes in neural activation as measured by functional neuroimaging. In the present …
in changes in neural activation as measured by functional neuroimaging. In the present …
A voxel-based morphometry (VBM) analysis of regional grey and white matter volume abnormalities within the speech production network of children who stutter
It is well documented that neuroanatomical differences exist between adults who stutter and
their fluently speaking peers. Specifically, adults who stutter have been found to have more …
their fluently speaking peers. Specifically, adults who stutter have been found to have more …
Improving drug delivery to intracerebral tumor and surrounding brain in a rodent model: a comparison of osmotic versus bradykinin modification of the blood-brain and …
RA Kroll, MA Pagel, LL Muldoon… - …, 1998 - journals.lww.com
OBJECTIVE: To compare transient blood-brain barrier disruption (BBBD) by hypertonic
mannitol with pharmacological modification of the blood-tumor barrier by the vasoactive peptide …
mannitol with pharmacological modification of the blood-tumor barrier by the vasoactive peptide …
Functional neuroimaging of cerebellar activation during single word reading and verb generation in stuttering and nonstuttering adults
F Luc, RM Kroll, S Houle - Neuroscience letters, 2001 - Elsevier
Articulatory discoordinations typically observed in fluent and disfluent speech of stuttering
adults suggest an underlying deficiency in the precise timing needed for speech production. …
adults suggest an underlying deficiency in the precise timing needed for speech production. …
Delayed administration of sodium thiosulfate in animal models reduces platinum ototoxicity without reduction of antitumor activity
LL Muldoon, MA Pagel, RA Kroll, RE Brummett… - Clinical Cancer …, 2000 - AACR
Platinum-based chemotherapeutic agents, such as carboplatin and cisplatin, are effective
against many human tumors, but their use may be limited by a high incidence of ototoxicity. …
against many human tumors, but their use may be limited by a high incidence of ototoxicity. …
Treatment intensity and childhood apraxia of speech
…, T Rietveld, B Maassen, R Kroll… - … journal of language …, 2015 - Wiley Online Library
Background Intensive treatment has been repeatedly recommended for the treatment of
speech deficits in childhood apraxia of speech (CAS). However, differences in treatment …
speech deficits in childhood apraxia of speech (CAS). However, differences in treatment …
The effects of simulated stuttering and prolonged speech on the neural activation patterns of stuttering and nonstuttering adults
Functional magnetic resonance imaging was used to investigate the neural correlates of
passive listening, habitual speech and two modified speech patterns (simulated stuttering and …
passive listening, habitual speech and two modified speech patterns (simulated stuttering and …
