746 CMAJ, July 12, 2016, 188 (10) erwise contraindicated. 1–3, 7 Patients will often have a
preferred opiate that they have found, with experience, to be effective. This patient should be …

Background: Pain, the hallmark complication of sickle cell disease (SCD), is largely
managed with opioid analgesics in the United States (1, 2). There is a common perception …

American Journal of Hematology 1 http://www3. interscience. wiley. com/cgi-
bin/jhome/35105 report having acute pain episodes 13% of the days, yet they only seek …

Pain, the hallmark complication of sickle cell disease (SCD), is largely managed with opioid
analgesics in the United States, but comprehensive data regarding the long‐term use of …

Severe acute pain is common in sickle cell disease (SCD). Increasingly overburdened
emergency departments are not the most appropriate setting in which to manage pain that …

A 19-year-old female patient with severe sickle cell disease (SCD) presented to her
hematologist with severe pain. Prior to 16 years, she reported 4 hospitalizations and 2 …

SIR—We read with interest the review article by Neri et al.(1) on the role of low-dose
ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell …

DISCUSSION Mrs. R is typical of someone with SCD who is well known to the health care
system. She makes multiple visits to the emergency department each year and is followed …

Background: Vaso-occlusive crises (VOC), also known as painful crises, are the hallmark of
sickle cell disease (SCD) and adults hospitalized with VOC are among the most severe …

Purpose Opioid analgesics are commonly used to treat vaso‐occlusive pain episodes in
sickle cell disease (SCD), but comprehensive evidence characterizing opioid use in this …