Background Warfarin is a highly efficacious oral anticoagulant, but its use is limited by a well-founded
fear of bleeding. Drug and food interactions are frequently cited as causes of …

Background: Decision aids have been shown to be useful in selected situations to assist
patients in making treatment decisions. Important features such as the format of decision aids …

As the end organ for the treatment of local diseases or as the route of administration for systemic
therapies, the lung is a very attractive target for drug delivery. It provides direct access to …

Research in the area of pulmonary drug delivery has gathered momentum in the last several
years, with increased interest in using the lung as a means of delivering drugs systemically. …

A new and regioselective strategy was developed for the preparation of fluorine-18-labeled
insulin as a novel positron emission tomography (PET) tracer. [ 18 F]-4-Fluorobenzoic acid (4…

Background Idiopathic pulmonary fibrosis (IPF) is a treatment resistant disease with poor
prognosis. Numerous compounds have been demonstrated to efficiently prevent pulmonary …

Conventional two-dimensional and three-dimensional single photon emission computed
tomography and positron emission tomography imaging tools and specific inhaled radiotracers …

Formation of pulmonary tertiary immune structures is a characteristic feature of advanced
COPD. In the current study, we investigated the mechanisms of tertiary lymphoid tissue (TLT) …

Streptococcus pneumoniae is a leading cause of invasive bacterial infections, with nasal
colonization an important first step in disease. While cigarette smoking is a strong risk factor for …

Emphysema is a major health problem and novel drugs are needed. Animal disease
models are pivotal in their development, but the validity and sensitivity of current tools for the …