Avibactam (formerly NXL104, AVE1330A) is a synthetic non-β-lactam, β-lactamase inhibitor
that inhibits the activities of Ambler class A and C β-lactamases and some Ambler class D …

Ceftolozane is a novel cephalosporin currently being developed with the β-lactamase inhibitor
tazobactam for the treatment of complicated urinary tract infections (cUTIs), complicated …

Relebactam (formerly known as MK-7655) is a non-β-lactam, bicyclic diazabicyclooctane, β-lactamase
inhibitor that is structurally related to avibactam, differing by the addition of a …

Between 1 September 2005 and 30 June 2006, 19 medical centers collected 4,180 isolates
recovered from clinical specimens from patients in intensive care units (ICUs) in Canada. …

Dalbavancin, oritavancin and telavancin are semisynthetic lipoglycopeptides that demonstrate
promise for the treatment of patients with infections caused by multi-drug-resistant Gram-…

Cefiderocol is an injectable siderophore cephalosporin discovered and being developed by
Shionogi & Co., Ltd., Japan. As with other β-lactam antibiotics, the principal antibacterial/…

Objectives To assess the proportion of Escherichia coli and Klebsiella pneumoniae from
Canadian hospitals that produce extended-spectrum β-lactamases (ESBLs), AmpC β-…

Eravacycline is an investigational, synthetic fluorocycline antibacterial agent that is structurally
similar to tigecycline with two modifications to the D-ring of its tetracycline core: a fluorine …

Objectives The purpose of the CANWARD study was to assess the antimicrobial activity of a
variety of available agents against 22 746 pathogens isolated from patients in Canadian …

A total of 5,282 bacterial isolates obtained between 1 January and 31 December 31 2008,
inclusive, from patients in 10 hospitals across Canada as part of the Canadian Ward …