Alcohol abuse is the most common cause of fatty liver disease, but it is now apparent that fat
deposition in the liver, and its consequences, may occur without alcohol abuse. The …

Background & Aims Some patients with nonalcoholic fatty liver disease (NAFLD) develop
liver-related complications and have higher mortality than other patients with NAFLD. We …

Background & Aims Histologic analysis of liver biopsy specimens allows for grading and
staging of nonalcoholic fatty liver disease (NAFLD). We performed a longitudinal study to …

Background & Aims: The natural history of nonalcoholic fatty liver disease (NAFLD) in the
community remains unknown. We sought to determine survival and liver-related morbidity …

Patients with nonalcoholic fatty liver disease (NAFLD) and advanced liver fibrosis are at the
highest risk for progressing to end‐stage liver disease. We constructed and validated a …

Nonalcoholic steatohepatitis (NASH) may present with increased hepatic fibrosis progressing
to end‐stage liver disease. No factors that determine increasing fibrosis and histologically …

BACKGROUND & AIMS:: The pathogenesis of nonalcoholic steatohepatitis (NASH) remains
poorly understood. Although apoptosis is a common mechanism of liver injury, the extent …

BACKGROUND/AIMS: The histological course of nonalcoholic fatty liver disease (NAFLD)
remains undescribed. Therefore, we examined the liver histology of NAFLD patients who had …

… Contributors: Leon Adams was the primary author, Paul Angulo provided scientific input,
and Keith Lindor was responsible for oversight, editing and scientific content. All of the authors …

No effective medical therapy is available for all patients with nonalcoholic steatohepatitis (NASH).
Ursodeoxycholic acid (UDCA) has been suggested to be of benefit based on open …