Engaged T cell antigen receptors (TCRs) initiate signaling through the adaptor protein Lat.
In quiescent T cells, Lat is segregated into clusters on the cell surface, which raises the …

… Dylan Owen received a degree in Physics, an MRes in Protein and Membrane Chemical
Biology and a Ph.D. in Biomedical Optics from Imperial College London, UK. His work has …

Lipid microdomains are postulated to regulate many membrane-associated processes but
have remained highly controversial. Here we provide the first direct evidence that the plasma …

Phosphorylation of the T cell antigen receptor (TCR) by the tyrosine kinase Lck is an essential
step in the activation of T cells. Because Lck is constitutively active, spatial organization …

Recently developed super‐resolution microscopy techniques are changing our understanding
of lipid rafts and membrane organisation in general. The lipid raft hypothesis postulates …

The mobility of membrane proteins is a critical determinant of their interaction capabilities
and protein functions. The heterogeneity of cell membranes imparts different types of motion …

Objective: To determine predictors of moderate or severe pain 6 months after orthopaedic
injury. Design: Prospective cohort study. Setting: Two adult level 1 trauma centers in Victoria, …

Orthopaedic injuries are common among trauma patients and can result in long-term problems.
Considerable data are available regarding functional outcomes following lower extremity …

Single-molecule localization-based super-resolution microscopy techniques such as
photoactivated localization microscopy (PALM) and stochastic optical reconstruction microscopy (…

Opioid tapering guidelines were created, in part, to decrease harm to patients resulting from
high-dose opioid therapy for chronic pain. However, countless “legacy patients” with chronic …