Background Patients with peripheral artery disease have an increased risk of cardiovascular
morbidity and mortality. Antiplatelet agents are widely used to reduce these complications. …

Background Coronary artery disease is a major cause of morbidity and mortality worldwide,
and is a consequence of acute thrombotic events involving activation of platelets and …

Conspectus Despite tremendous research efforts in universities and pharmaceutical
companies, effective drugs are still lacking for the treatment of Alzheimer’s disease (AD). The …

Background Inhibition of leukocyte adhesion can reduce myocardial infarct size in animals.
This study was designed to define the safety and efficacy of a recombinant, humanized, …

Functional analysis of a genome requires accurate gene structure information and a complete
gene inventory. A dual experimental strategy was used to verify and correct the initial …

Conspectus With the increase of life expectancy of humans in more than two-thirds of the
countries in the World, aging diseases are becoming the frontline health problems. Alzheimer’s …

Droplet single-cell RNA-sequencing (dscRNA-seq) has enabled rapid, massively parallel
profiling of transcriptomes. However, assessing differential expression across multiple …

Expression of tissue-restricted self antigens (TRAs) in medullary thymic epithelial cells (mTECs)
is essential for the induction of self-tolerance and prevents autoimmunity, with each TRA …

The challenge of linking intergenic mutations to target genes has limited molecular
understanding of human diseases. Here we show that H3K27ac HiChIP generates high-resolution …

The genome of the flowering plant Arabidopsis thaliana has five chromosomes 1 , 2 . Here
we report the sequence of the largest, chromosome 1, in two contigs of around 14.2 and 14.6 …